TGF-β is also a key cytokine that contributes to the activation of Treg and tumor angiogenesis [22], which blocks the IFN-mediated expression of MHC-II molecules, inhibit the differentiation and maturation of APCs, inhibit the production of perforin and granzyme, and thereby impair T cell function [24]. This evidence concerns the gene TGFB1 and neoplasm.