By MCC analysis (Figure 7), we decided 10 potential hub genes in the pancreas islet blamed for T2DM: MEDAG, EDNRB, DDX21, SERPINF1, ELK3, IL33, SMOC2, IL24, CLMP, and MFAP4. These 10 genes had the highest MCC value in the subnetwork and thus had the strongest coexpression relationships with other genes in the whole subnetwork. Here, SMOC2 is linked to type 2 diabetes mellitus.