According to the criteria mentioned before, MEDAG (cor = 0.404, p = 0.001), SERPINF1 (cor = 0.532, p = 6.98E − 6), IL33 (cor = 0.451, p = 2.02E − 4), SMOC2 (cor = 0.422, p = 5.66E − 4), IL24 (cor = 0.438, p = 3.35E − 4), CLMP (cor = 0.420, p = 6.06E − 4), and MFAP4 (cor = 0.440, p = 3.03E − 4) are identified as real hub genes for T2DM. This evidence concerns the gene SERPINF1 and type 2 diabetes mellitus.