ELK3 and type 2 diabetes mellitus: By MCC analysis (Figure 7), we decided 10 potential hub genes in the pancreas islet blamed for T2DM: MEDAG, EDNRB, DDX21, SERPINF1, ELK3, IL33, SMOC2, IL24, CLMP, and MFAP4. These 10 genes had the highest MCC value in the subnetwork and thus had the strongest coexpression relationships with other genes in the whole subnetwork.