In the state of Amazonas, the correlations between the prevalence of both P.1 lineage and E484K variants, and the number of COVID-19 deaths in the following weeks were positive, statistically significant and strongest in the two weeks following the detection of the mutations (Spearman Rho=0.71; R2=51.1%; p<0.01; n=14). The gene discussed is OCA2; the disease is COVID-19.