SD = standard deviation; LDL = low density lipoprotein; Hb = hemoglobin; NIHSS = National Institute of Health Stroke Scale; tPA = tissue plasminogen factor; LKW = last known well; TICI = thrombolysis in cerebral infarction; mRS = modified Rankin Score; CSVD = cerebral small vessel disease. This evidence concerns the gene PLAT and cerebral small vessel disease.