The present study showed that the combination treatment resulted in the upregulation of a set of miRNAs (miR‐15b, ‐214 and ‐125b) in sciatic nerve tissue and cancer cells, which were inversely associated with protein levels of TRPV1 and Sarm1 in the nerve tissue, and GRASP55 and β‐catenin proteins in ovarian tumour, respectively. The gene discussed is TRPV1; the disease is ovarian neoplasm.