TNF and metabolic dysfunction-associated steatotic liver disease: Furthermore, lycopene extracted from tomato could dose-dependently improve the liver function and lipid profiles in the NAFLD rat model by decreasing the levels of cytochrome P450 2E1 (CYP2E1), malondialdehyde (MDA), and tumor necrosis factor-α (TNF-α) in the liver [86–88].