In summary, some studies reported that coffee and its bioactive compounds (like caffeic acid, trigonelline, and caffeine) could be beneficial for NAFLD prevention through improving hepatic steatosis, insulin resistance, oxidative stress, gut permeability, and autophagy (Table 1), with regulating phosphorylation of mTOR and the expression of PPAR-α/γ, SREBP-1c, and TLR4, as well as activating the SIRT3-AMPK-ACC signaling pathway (Figure 2). The gene discussed is SREBF1; the disease is fatty liver disease.