In addition, in vivo studies also showed that the oral administration of resveratrol and anthocyanin extracted from grape improved lipid metabolism, oxidative stress, and inflammation in the NAFLD mouse model by downregulating PPAR-γ while upregulating Nrf2 and SIRT1 signaling pathways, accompanied by decreasing the expression of fatty acid synthase (FAS) and sterol regulatory element-binding transcription factor 1c (SREBP-1c) [81, 84]. This evidence concerns the gene SIRT1 and metabolic dysfunction-associated steatotic liver disease.