Several double-blind randomized placebo-controlled clinical trials showed that the intake of 500 mg of green cardamom 3 times per day for 3 months could decrease the degree of fatty liver in NAFLD patients, accompanied by decreasing the levels of ALT, CRP, TNF-α, and IL-6, as well as increasing the serum level of SIRT1 [159]. This evidence concerns the gene SIRT1 and fatty liver disease.