TNF and fatty liver disease: Besides, Zhijuzi (Hovenia dulcis) could alleviate hepatic steatosis and inflammation in the AFLD rat model by upregulating the expressions of PPAR-α, CPT-1α, and long-chain fatty acid CoA ligase 1 (Acsl1), as well as downregulating the expressions of myeloid differentiation factor 88 (Myd88), TNF-α, and C-reactive protein (CRP) [145].