In short, some fruits (such as mulberry, berries, lychee, and lemon), as well as their bioactive compounds (such as resveratrol, flavonoids, and phenolic extracts) could alleviate AFLD mainly due to the promotion of ethanol metabolism and the inhibition of liver cell apoptosis, as well as the improvement of hepatic steatosis, oxidative stress, inflammation, and gut dysbiosis (Table 1) with regulating AMPK, PPAR-α, Nrf2, and SIRT1 signaling pathways (Figure 3). The gene discussed is NFE2L2; the disease is fatty liver disease.