NFE2L2 and fatty liver disease: Furthermore, phenolic extracts from lychee could alleviate AFLD in C57BL/6 mice by improving hepatic steatosis, oxidative stress, and gut dysbiosis, with upregulating the Nrf2 pathway and decreasing the levels of cytochrome c, caspase-3, and the ratio of Bcl2-associated X protein (Bax) to B-cell lymphoma-2 (Bcl-2) [98, 99].