In summary, several fruits (like grape, cherry, tomato, and mulberry) and their bioactive compounds (like resveratrol, anthocyanin, and lycopene) could be promising agents against NAFLD due to their outstanding effects on regulating lipid metabolism, oxidative stress, inflammation, and gut microbiota (Table 1), with regulating AMPK, PPAR-α/γ, Nrf2, mTOR, and Akt signaling pathways (Figure 2). The gene discussed is MTOR; the disease is metabolic dysfunction-associated steatotic liver disease.