Meanwhile, resveratrol is also a main compound in red wine and could improve the hepatic steatosis and redox homeostasis in HepG2 cells by upregulating the protein kinase A- (PKA-) AMPK-PPAR-α signaling pathway and regulating the epigenetic modification of the Nrf2 signaling pathway [80, 81]. This evidence concerns the gene NFE2L2 and fatty liver disease.