According to a rat trial conducted by Yi about CDD on obesity-type PCOS, the result showed that CDD decreased the serum levels of TCHO, TG, LDL-c, LH, T, IL-1β, IL-6, and TNF-α and increased the levels of HDL-c, FSH, and E2 in a dose-dependent manner. Here, PLOD1 is linked to obesity due to melanocortin 4 receptor deficiency.