After 3 months, they found that, in obese PCOS patients, acupuncture can effectively improve the ovarian function by regulating the luteinizing hormone (LH), the follicle-stimulating hormone (FSH), and the testosterone (T) and reducing LH/FSH, leptin (LEP), and obesity. The gene discussed is BRD2; the disease is obesity due to melanocortin 4 receptor deficiency.