NOS1 has great significance in controlling salt-water balance, and blood pressure, especially the long-term blockade of NOS1 by 7-NI, a specific inhibitor of NOS, leads to hypertension in rats [55], while NO through NOS2 during inflammation increases oxidative and nitrative stress, causing neurodegeneration and enhancement of apoptosis [56]. This evidence concerns the gene NOS2 and Hypertension.