In summary, the obtained results suggest that regions 8q22-24, 11q23-25, and 12q13-15 are very likely to contain genes like VPS13B, APOA5, ZPR1, BUD13, and FAIM2 that control obesity-related factors in Iranian families with MetS21,22,27,28,31,32. Here, APOA5 is linked to obesity due to melanocortin 4 receptor deficiency.