Exome sequencing studies have identified at least 20 mutations in the Cul3 gene (13 protein-truncating mutations and 7 missense) in the patients with autism spectrum disorder (ASD), developmental delay (DD), and schizophrenia (SCZ), with no Cul3 mutations detected in healthy controls (Fig. 1a, Supplementary Table S1). Here, CUL3 is linked to autism spectrum disorder.