CUL3 and dentin dysplasia: Exome sequencing studies have identified at least 20 mutations in the Cul3 gene (13 protein-truncating mutations and 7 missense) in the patients with autism spectrum disorder (ASD), developmental delay (DD), and schizophrenia (SCZ), with no Cul3 mutations detected in healthy controls (Fig. 1a, Supplementary Table S1).