Several putative clinical factors (hypertension and proteinuria)20, tissue markers (VEGF-A, VEGFR2, c-Met)16,21,22, circulating biomarkers (MMP2)23, imaging perfusion and diffusion maps24 and molecular markers (EGFR, Proneural subtype)25–27 have been investigated, although they lack validation and confirmation among studies. This evidence concerns the gene MMP2 and hypertensive disorder.