In this study we tested the hypothesis that genetic variability in PHACTR1 may have significantly influenced the risk for ischemic stroke, either increasing the susceptibility to small vessel ischemic and CADASIL-like diseases in patients or regulating the recruitment and plasticity of PcomAs in 2 C57BL/6J experimental stroke mouse models (BCCAS and MCAO). The gene discussed is PHACTR1; the disease is Stroke.