Whereas infection of NRVMs with AdXBP1s resulted in increases in SKP2 mRNA (Supplementary Fig. 10a), SKP2 knockdown using SKP2-specific siRNA (siSKP2) did not relieve Xbp1s-dependent FoxO1 protein degradation (Supplementary Fig. 10b). This evidence concerns the gene FOXO1 and infection.