More apoptotic cells were observed after Rp infection than in uninfected AAE2 cells (Fig. 1A and B; panel 1, early phase of apoptosis, annexin V-FITC positive and PI negative; panels 2 to 4, late phase of apoptosis, both annexin V-FITC and PI positive; panels 5 and 6, terminal [dead cells] phase of apoptosis, annexin V-FITC negative and PI positive). The gene discussed is ANXA5; the disease is infection.