TLR7 and systemic lupus erythematosus: DN B cells,47 which are considered part of the memory compartment since they are class-switched, are expanded in SLE patients with high disease activity.48 Recent studies have shown that subclasses of DN B cells (DN2), which are TLR7 hyper-responsive, may promote SLE pathogenesis via their propensity to differentiate into plasmablasts following TLR7 activation.49 Overall, the relative increase in naïve B cells and DN B cells indicates that iberdomide is able to inhibit the TLR7 driven differentiation of B cells into plasmablasts.