For example, we identified: NOTCH1, whose blockade ameliorates SLE in animal models;50ZNF609, a circular RNA implicated in lupus nephritis;51NCOR2, relevant for the regulation of interferon production;52MYCBP2, a newly described E3 ubiquitin-protein ligase;53SRRM2, a splicing factor gene, with polymorphisms linked to SLE;54MDN1, a human chaperone recently identified as a relevant factor in autoimmunity;55RUNX1, a transcription factor associated with a number of autoimmune conditions, including rheumatoid arthritis, psoriasis and SLE.56 This evidence concerns the gene NOTCH1 and systemic lupus erythematosus.