CASP1 and systemic lupus erythematosus: Similarly, analyses of differentially regulated genes in plasmablasts treated with iberdomide identified a number of genes known to be involved in the pathogenesis of SLE, such as immunoglobulin related genes (eg, IGKV2D-10; IGLV3-17; IGHV1-45); CASP1, encoding caspase-1, shown to be essential for the development of lupus in animal models;57FGL2, fibrinogen-like 2, for which deletion leads to autoimmune glomerulonephritis.58