Stratifying the Mayo and the UW samples according to SNP24 genotypes revealed a decreasing tendency in SORL1-38b levels in carriers of the risk genotype T/T of SNP24 (rs2282649) (Fig. 5d, e) (pmeta = 0.14, analysis adjusted for AD status) (Fig. 5f). Here, SORL1 is linked to Alzheimer disease.