Bai S’s study had also proven that EGFL6 promotes the asymmetric division of cancer stem-like cells in ovarian cancer [29], consistent with this research’s result that EGFL6 could keep the cell stemness by regulating the expression of cancer stem cell associated genes, POU5F1, NANOG, and LIN28 (Fig. 4d, e). Here, POU5F1 is linked to ovarian cancer.