EGFL6 and colorectal carcinoma: Both EGFL6-E5-IgG and bevacizumab significantly inhibited CT-26 metastasis compared to the Control group (* p < 0.05 and ** p < 0.01, respectively) without significant differences between two treated groups (Fig. 5b), indicating that EGFL6 blockade can suppress CRC cell metastasis in vivo and EGFL6-E5-IgG’s potential effectiveness.