In summary, using a series of biological analyses, we have obtained a new understanding and description of human bronchial organoids infected with novel coronavirus, and through the analysis and verification of differential genes, we have identified that CXCL1, CCL5, EGF, CXCL10, and CXCL8 play a key role in the infection process in novel coronavirus and a series of pathways related to cytokine expression, leukocyte migration, and cytokine-cytokine receptor interaction have been significantly changed. Here, CCL5 is linked to infection.