In conclusion, by studying the mRNA expression of human bronchial organoids, we have found that a series of DEGs (CXCL1, CCL5, EGF, CXCL10, CXCL8), which were also reported in SARS-CoV-2 infected patients, in vitro and in vivo models, plays an important role in the COVID-19 and are helpful for diagnosis and treatment. The gene discussed is EGF; the disease is COVID-19.