TP53 and cancer: Considering both SKOV3 and A2780 cells have some inherent defects, such as flat copy-number profiles, wild-type TP53 and uncharacteristic mutations [39], which may not completely reflect the real situation of ovarian cancer because ovarian cancer in natural state is a group of heterogeneous tumors, we additionally selected EVs from ascites of high-grade serous ovarian cancer patients and still observed the effect of cancer-secreted EVs to induce the MMT process of mesothelial cells.