In our study none of the previously reported mutations in North African patients was identified except for the c.1310_1313delAAGA in BRCA2. Indeed, this mutation was detected in 4% (4/98) of patients from unrelated families with high risk of BC and among 9 BRCA2 carriers, 4 (44.4%) had the c.1310_1313delAAGA mutation suggesting that it might be recurrent in our population. The gene discussed is BRCA2; the disease is breast cancer.