In addition, survival analysis of these 20 genes showed that 5 genes (CCNB1, KIF20A, ASPM, AURKA, and KIF23) were significantly related to a poorer OS in EOC patients, which may be partly attributed to the tumor immunosuppressive microenvironment when performing the Pearson correlation analysis between 5 core genes’ expression and the level of different immune checkpoint proteins. This evidence concerns the gene ASPM and neoplasm.