Since circulating MPs from patients with acute coronary syndrome induced premature endothelial senescence and thrombogenicity involving the local pro-oxidant angiotensin system [13], experiments were performed to determine whether circulating MPs from CAD patients induce SGLT1 and 2 expression in ECs and, if so, to clarify their role in the induction of endothelial dysfunction. This evidence concerns the gene SLC5A1 and coronary artery disorder.