AGT and endothelial dysfunction: They further indicate that SGLT1 and SGLT2 protein levels are up-regulated ex vivo in pathological rat arteries (i.e., aortic arch, Ang II- and eNOS inhibitor-treated thoracic aorta vs. thoracic aorta) promoting oxidative stress in the arterial wall and endothelial dysfunction most likely subsequent to the impaired endothelial formation of NO.