The CAD-MPs from 11 out of 15 patients increased in ECs the protein expression level of both SGLT1 and 2, 15/15 patients that of VCAM-1, and 12/15 patients down-regulated that of eNOS (Fig. 7a–d, Additional file 1: Figure S2A–D). Here, VCAM1 is linked to coronary artery disorder.