To obtain physiological relevance, the expression level of SGLT1 and 2 proteins was assessed ex vivo at arterial sites either at high (aortic arch characterized by premature endothelial dysfunction and exposure to disturbed flow and low shear) or low risk (thoracic aorta protected by laminar flow and the high shear-induced endothelial formation of NO) [2]. This evidence concerns the gene SLC5A1 and endothelial dysfunction.