SLC5A1 and endothelial dysfunction: Moreover to assess the physiological relevance, experiments have investigated the expression level of SGLT1 and 2 at an arterial site prematurely affected by endothelial dysfunction and exposed to disturbed flow and low shear stress (aortic arch) and an arterial site at low risk exposed to laminar flow and high shear stress (thoracic aorta), and also in thoracic aorta segments exposed to either Ang II or following inhibition of the endothelial formation of NO in adult rats.