PIK3CA and cancer: By contrast, the mechanism underlying the regulatory effects of CDC42EP3 on colorectal cancer were demonstrated through the detection of cancer-related signaling including Akt, CDK6, Cyclin D1 and PIK3CA, a reflection of the downregulation of Akt, p-Akt, CDK6, Cyclin D1 and PIK3CA (Fig. 5f).