The transient receptor potential melastatin-subfamily member 7 (TRPM7) and the store-operated calcium (SOC) channels comprising of calcium release-activated calcium channel protein 1 (ORAI1) and stromal interaction molecule 1 (STIM1) are the major pathways of Ca2+ entry and intracellular signaling in both cancer and most excitable cells [11–13]. Here, TRPM7 is linked to cancer.