Genetic inhibition of ITGA4 and ITGB7 by CRISPR/Cas9 in MM cells, designated as sgITGA4 and sgITGB7 cells (Fig. 6A and B), also showed a substantial reduction in MM cell migration and invasion when compared to WT control (Fig. 6C and D), while having minimal effect on cell proliferation, cell cycle and apoptosis (Additional file 2: Fig. S20). Here, ITGB7 is linked to Miyoshi myopathy.