Based on the findings that inhibition of TRPM7, ORAI1, and STIM1 elevated cellular O-GlcNAcylation level, and that inhibition of such channels and O-GlcNAcylation reduced MM cell migration and invasion, we postulated that TRPM7, ORAI1, and STIM1 may regulate MM cell motility through O-GlcNAcylation. This evidence concerns the gene ORAI1 and Miyoshi myopathy.