CDH5 and neoplasm: It should be noted, however, that as VE-cadherin is a component of intercellular adherens junctions in endothelial cells and plays an important role in regulating vascular permeability [29], downregulation of VE-cadherin in endothelial junctions by siANGPTL4 may increase tumor vascular permeability and subsequently increase the risk of tumor metastasis and spread [30].