However, several studies have claimed that ANGPTL4 inhibits vascular angiogenesis and prevents tumor metastasis in melanoma B16F0, lung cancer 3LL [10] and colon cancer CMT93 [9] xenograft mouse models; however, contrasting results were observed in breast cancer [11], renal cell carcinoma [14], and ovarian cancer [16, 17] xenograft models, indicating that ANGPTL4 may act as a tissue-specific and multifunctional vascular modulator. This evidence concerns the gene ANGPTL4 and melanoma.