As VEGFR2 Y949 plays an important role in tumor vascularization and growth [19], this tyrosine (Y) in VEGFR2 was mutated to phenylalanine (F) and spontaneous ovarian carcinoma was induced in siANGPTL4-injected mice to further determine the connection between ANGPTL4 and VEGFR2 pY949 in tumors. The gene discussed is KDR; the disease is ovarian carcinoma.