The results presented in these publications are inconclusive, so in this study, we decided to evaluate the levels of IL-1β, CXCL8, and TNF-α in PISF obtained from patients without clinical symptoms of mucositis or peri-implantitis and compared them with the levels of mediators in GCF obtained from patients with healthy periodontitis and with varying degrees of periodontitis. The gene discussed is CXCL8; the disease is Peri-Implantitis.