The results presented in these publications are inconclusive, so in this study, we decided to evaluate the levels of IL-1β, CXCL8, and TNF-α in PISF obtained from patients without clinical symptoms of mucositis or peri-implantitis and compared them with the levels of mediators in GCF obtained from patients with healthy periodontitis and with varying degrees of periodontitis. This evidence concerns the gene TNF and Peri-Implantitis.