Moreover, we found no evidence for afunctional association between the OPRM1 polymorphism and AD.Descriptively, there were proportionally more G+ carriers among the HCs comparedto the AD group – from the literature we would have expected the reverse results– although this difference was formally not statistical significant(χ2(df = 1) = 3.62,p = 0.06). The gene discussed is OPRM1; the disease is Alzheimer disease.