Moreover, we found an interaction between instrumentalaction, OPRM1 polymorphism and group, indicating that theopioid system differently affects instrumental responses in AD patients and HCs.Exploratory post hoc analyses (Supplementary Information 4) indicated that AD G+ carriersshowed increased ‘Go’ responses compared to ‘No-Go’ responses, whereas HC G+carriers showed increased ‘No-Go’ responses compared to ‘Go’ responses. The gene discussed is OPRM1; the disease is Alzheimer disease.