[4] Low-dose oral THC inhibits atherosclerosis progression via pleiotropic immunomodulatory effects in apolipoprotein-E knockout models,[9] as well as inhibiting lymphoid proliferation and macrophage chemotaxis, in a dose-dependent manner.[4,9] This effect can also be inhibited by a CB2 antagonist.[4] A similar function was observed for CB2 in vascular smooth muscle cells in coronary arteries. Here, APOE is linked to atherosclerosis.