Gonadotropin-releasing hormone agonist (GnRH-a) drugs are known to be used in the clinical treatment of EMS,[7] the development of lesions can be controlled by maintaining the low hormone level in patients, and the condition of patients can be improved.[8] Leuprorelin acetate is a GnRH-a drug, but long-term use will cause perimenopausal symptoms such as insomnia, hot flashes, memory loss, and so on.[9]. Here, GNRH1 is linked to insomnia.