Hirofumi Bekki et al. reported that phosphorylation of STAT3 in undifferentiated pleomorphic sarcoma was correlated with a favorable prognosis.[47] R Lai et al found that among 31 patients who presented with localized Ewing sarcoma, high-level STAT3 activation correlated with better OS.[48] Similarity, Nokitaka Setsu et al also reported that activator of STAT3 in soft tissue leiomyosarcoma is associated with a better prognosis.[49] Research had shown that high expression of PLCG2 can promote the activation of IL2 and STAT3 in TME,[50] which is consistent with our GSEA results. Here, PLCG2 is linked to Ewing sarcoma.