PLCG2 and neoplasm: Some researchers showed that NK cells arrive early in the TME and cooperate with dendritic cells resulting in effective immune responses mediated by CD8T cells.[62,63] In particular, PLCG2 was shown to be vital for cellular cytotoxicity in natural killer (NK) cells.[64] Therefore, the higher the expression of PLCG2, the lower the resting NK cell density, which suggests that the regulation of the activity of resting NK cells might play an anti-tumor role.