Previous studies using preclinical models showed the impact of CD8+ T cells on the suppression of tumor cell growth, tumor infiltration inhibition, and the regulation of complete tumor elimination.[52–54] Similarly, several studies have indicated that gamma delta T cells can kill a wide range of tumor cells from both solid tumors and hematopoietic malignancies.[55,56] Macrophages can be activated by a variety of different cytokines within the microenvironment. The gene discussed is CD8A; the disease is neoplasm.