TIMP3 and cancer: Tissue inhibitor of metalloproteinase 3, a member of the TIMP family, is located on the long arm of chromosome 22 at position 12.3 (22q12.3), which functions as the antagonist of MMPs to guard homeostasis and affect physiological tissue remodeling and developmental processes by regulating cell growth, invasion, migration, apoptosis, and angiogenesis.[22,25] Furthermore, genetic variation in TIMP3 has been linked with susceptibility to cardiovascular disorders and cancers.