INS and Infertility: PCOS is one of the main causes of anovulatory infertility, which accounts for 25% to 30% of anovulatory infertility,[4] the incidence is about 5.6% in China.[5] Data show that treatment PCOS infertile IVF alone costs about 100 billion.[6] PCOS assisted pregnancy has become a difficult point in the treatment of infertility.[7] With the development of PCOS pathogenesis, ovulation promotion drug therapy and insulin sensitizer therapy have become the focus of PCOS pregnancy therapy.