For example, the upregulation of urothelial carcinoma-associated 1 (UCA1) promoted the proliferation and inhibited the apoptosis of ACC cells though the miR-298-CDK6 axis.[49] Overexpression of HOX transcript antisense RNA (HOTAIR), by regulating the cell cycle, led to the poor OS in ACC.[50] High expression of topoisomerase alpha 2 (TOP2A) was demonstrated to activate ACC cell proliferation, with TOP2A representing a potential therapeutic target.[51] We tried to explore the relationships between m6A-related genes and these ACC-driver genes. This evidence concerns the gene UCA1 and adrenal cortex carcinoma.