METTL3 and adrenal cortex carcinoma: For example, the upregulation of METTL3 has been found to inhibit the proliferation, migration and invasion of colorectal cancer cells by p38/ERK pathways[15] and predict poor prognosis in hepatocellular carcinoma.[16] In cervical squamous cell carcinoma, FTO expression was found to be upregulated in tumor tissues and to regulate chemoradiotherapy resistance by targeting beta-catenin.[17] However, the relationships between m6A-related genes and ACC remain unknown.