GPT and Renal insufficiency: 3. Patients with severe primary diseases like heart, brain, liver, kidney, hemopoietic system-related diseases, and patients whose Alanine Aminotransferase or Aspartate Transaminase is higher than 1.5 times of the upper limit, patients with renal insufficiency (serum creatinine > 194.5 μmol/L) or insulin-dependent diabetes mellitus.