PLAT and severe acute respiratory syndrome: Only hydration and mobilization are recommended in these cases.[37] Involvement of fibrin production in development of severe SARS leaded some physicians to treat some COVID-19 patients with recombinant tissue plasminogen activator, but with only transient clinical improvement.[47] For the moment no interaction has been observed between investigational drugs to treat COVID-19 and parenteral anticoagulation, but particular attention should be paid for VKA and direct oral anticoagulants.[48]