TSPO and early-onset autosomal dominant Alzheimer disease: However, other TSPO PET studies using [11C]DAA1106 in cognitive impairment-dementia, [18F]FEDAA1106 in multiple sclerosis [19] and [18F]DPA-714 [34] or [18F]FEDAA1106 [35] in Alzheimer’s disease reported no significant differences.