Besides, the cardiac transcriptome revealed that a high-fibre diet or acetate supplementation resulted in the upregulation of genes (Tcap [titin-cap] [142] and Timp4 [tissue inhibitor of metalloprotease 4] [143]) that are strongly considered to have a preventive role for heart disease; whilst EGR1 (early growth response protein 1), a master cardiovascular regulator [144–146], was downregulated in both the heart and kidney. The gene discussed is EGR1; the disease is heart disorder.