CCL2 and obesity due to melanocortin 4 receptor deficiency: Obesity related adipocyte hypertrophy was also shown to be positively correlated with the expression of inflammatory genes [78], increased pro-inflammatory adipokine secretion (e. g., IL-6, IL-8, MCP-1) [79], and reduced secretion of anti-inflammatory adipokines (e. g., adiponectin), contributing to an increased inflammatory response in adipose tissue [80].