WDR81 and microcephaly: Alazami et al. identified a case carried the homozygous mutation of c.845G>A (Gly282Glu) presented with neonatal death due to severe hydranencephaly and cerebellar hypoplasia and the initial phenotype was CAMRQ2 (Alazami et al., 2015), this case was uncover the same mutation and the phenotype was similar to one of the case reported by Shaheen et al. Mutation of WDR81 also proposed associated with sever microcephaly.