Recently, conditional deletion of Smad7, a negative regulator of TGF‐β/SMAD pathway, led to sustained melanoma growth and at the same time promoted metastasis formation (Tuncer et al,2019), confirming that TGF‐β/SMAD pathway is a promising target for melanoma (Javelaud et al,2007). The gene discussed is SMAD7; the disease is melanoma.