We postulated that BRAFi‐resistance genes are highly expressed in BRAFi‐resistant cells (n = 6) as already demonstrated by other approaches for NRP1, AXL, and NGFR. To this end, we confronted CRISPR‐SAM candidates (identified in 501Mel cells) to gene expression data from six melanoma cell lines that were highly resistant to BRAFi according to the Cancer Cell Lines Encyclopedia (CCLE) versus six sensitive cell lines (Barretina et al,2012; Fig 2E). The gene discussed is AXL; the disease is cancer.