BIRC3 and neoplasm: Since our results suggest that a high expression level of these tumor‐promoting genes is sufficient to promote melanoma tumor growth, we evaluated the biological consequences of the inhibition of one tumor‐promoting gene, BIRC3. The chemical inhibitor Birinapant reduced the SKMel28R and Me1402 cell density (Fig EV1B and C), suggesting that the BIRC3 protein is involved in cell proliferation of these melanoma cells as previously demonstrated (Krepler et al,2013; Vetma et al,2017).