PDE5A and COVID-19: Reviewed data indicate that PDE5 inhibitors could be effective in managing patients with COVID-19 by counteracting the Ang-II–mediated downregulation of the AT-1 receptor, exhibit action on monocyte switching, reducing proinflammatory cytokines and interstitial infiltration; and inhibit the transition of endothelial and smooth muscle cells to mesenchymal cells in the pulmonary artery, preventing clotting and thrombotic complications.