CD46 and schizophrenia: Excessive synaptic pruning is thought to be one of the underlying causes of schizophrenia (Sellgren et al., 2019), and three large-scale genetic susceptibility studies have identified the CD46 gene as a significant Schizophrenia-risk locus (Håvik et al., 2011; Kim et al., 2020; Ripke et al., 2014).