IFNA1 and COVID-19: Although SARS coronaviruses have evolved diverse strategies to evade the antiviral effects of IFNs (Kindler et al., 2016), IFN signaling nonetheless remains a potent defense mechanism against SARS-CoV-2, as illustrated by the fact that both genetic variants compromising IFN signaling and autoantibodies against IFN ligands have been associated with severe COVID19 (Bastard et al., 2020; Zhang et al., 2020).