NEO1 and cancer: NEO1 was described as a homolog of Deleted in Colorectal Cancer (DCC), as these proteins share about 50% amino acid identity and possess the same secondary structure, consisting of an extracellular domain that contains four Immunoglobulin-like loops and six repeated Fibronectin-III (FNIII) type regions, followed by a single transmembrane region and a cytoplasmic tail, containing three domains conserved with DCC, referred to as P1, P2 and P3 [11].