Nevertheless, this could as well be a sign of its antidepressant action, since recent reports demonstrated that glial GLT-1 blockade in mPFC contributes to the rapid onset of ketamine antidepressant effects [38, 39] and the astrocytic GLT-1 deficiency correlates to decreased anxiety and depression in a mouse model [40]. This evidence concerns the gene SLC1A2 and depressive symptom measurement.