PDGFRB and early-onset autosomal dominant Alzheimer disease: When Alzheimer’s disease patients and controls were stratified according to systemic infection, one-way ANOVA indicated that PDGFRβ did not differ between groups according to the presence of infection (Fig. 2D); however, a weak but significant effect of systemic infection on PDGFRβ was observed for Alzheimer’s disease patients versus controls (Supplementary Table 2; interaction effect, P = 0.039) but not for vascular dementia versus controls running a two-way ANOVA.