In the absence of infection or substantial Alzheimer’s disease tangle pathology (i.e. in BS 0–II), cortical perfusion, as indicated by MAG:PLP1, correlated negatively with the levels of several cytokines (IFN-γ, IL-2, IL-12p70, IL-6, IL-10, IL-13, IL-4) but with few exceptions this correlation was lost with infection or progression of tangle pathology (Fig. 4). The gene discussed is IL6; the disease is early-onset autosomal dominant Alzheimer disease.