PLP1 and early-onset autosomal dominant Alzheimer disease: As previously reported in the precuneus, fibrinogen level in the superior temporal cortex was inversely corelated with markers of cerebral hypoperfusion (reduced MAG:PLP1 and elevated VEGF) (Supplementary, Fig. 6A and B) and positively correlated with amyloid-β42 in controls and Alzheimer’s disease cases, but not vascular dementia (Supplementary, Fig., 6C).