Modelling of acute systemic infection in rodents induces microglial activation and elevated pro-inflammatory cytokine production (IL-1β, IL-6 and TNF-α), and exacerbates cognitive decline, neurodegeneration, and Alzheimer’s disease-like (amyloid-β and tau) pathology in mouse models.8-11. This evidence concerns the gene IL6 and early-onset autosomal dominant Alzheimer disease.