INS and breast cancer: Peripheral adiposity is associated with more favourable metabolic health than abdominal adiposity, with greater insulin sensitivity and a more favourable inflammatory profile, and may therefore be associated with lower cancer risk than central adiposity.30 However, in the current study and in a previous study among normal weight women from the Women’s Health Initiative cohort,5 peripheral adiposity was shown to be associated with increased risk of postmenopausal breast cancer.