Peripheral adiposity is associated with more favourable metabolic health than abdominal adiposity, with greater insulin sensitivity and a more favourable inflammatory profile, and may therefore be associated with lower cancer risk than central adiposity.30 However, in the current study and in a previous study among normal weight women from the Women’s Health Initiative cohort,5 peripheral adiposity was shown to be associated with increased risk of postmenopausal breast cancer. The gene discussed is INS; the disease is cancer.