That being said, independent reports have supported the applicability of this combination in vivo, using either a MYC-driven lymphoma model or against a neuroblastoma model.122,123 Mechanistic insights from these studies were lacking, but based on gene expression profiles of neuroblastoma cells treated with BETi+HDACi, a large panel of genes are regulated in a synergistic manner, including MYC transcriptional networks. This evidence concerns the gene MYC and neuroblastoma.