I-BET762 was initially characterised as a chemical means to reduce inflammation.30 By dissociating BET-family members from enhancer regions, I-BET762 downregulates a set of pro-inflammatory genes in activated macrophages in vitro and reduced inflammation in murine sepsis models.30 Subsequent to these findings, I-BET762 was tested against a number of preclinical cancer models. Here, DNER is linked to cancer.