BCL2 and cancer: A short hairpin (sh)RNA screen revealed that BRD4 is essential for the proliferation of ovarian carcinomas and that BRD4 depletion significantly reduced cancer cell viability.26 Similarly, BRD4 upregulation has been found in renal cell carcinoma, and subsequent inhibition of its expression with shRNAs induced cell cycle arrest.27 BRD3 and BRD4 promote cell cycle progression and resistance to apoptosis in cancer by upregulating anti-apoptotic family members including BCL-2 and the cyclin-dependent kinase CDK6.28