DNER and cancer: Studies using BETi indicate this role might be dependent on the recruitment of BET-family members to super-enhancers—large genomic regions containing several enhancers in close proximity—where they aberrantly activate oncogenes.10 Among the BET-family members, the overexpression of BRD4, in particular, appears to transcriptionally activate target genes that play key roles in cell cycle progression and survival/repression of apoptosis across cancer types.