PROS1 and cancer: LIMCH1 positively regulates actin stress fibres assembly and stabilises focal adhesions through interaction with the actin-based motor protein non-muscle myosin II.26,27 LIMCH1 has been found to participate in the specific carcinogenesis of various types of cancer, including breast cancer, renal cancer and lung adenocarcinoma.28–30 In line with this, we found that LIMCH1high tumours associate with high LIMCH1 gene levels, rare histological types, high grade and poor outcome in cervical cancer.