When evaluating gene expression patterns in PD-L1high tumours by GSEA, only 24% of the significantly enriched GO gene sets (false discovery rate < 0.05) related to immune activation (Supplementary Table 10), indicating that HLA-DQB1 may be a stronger predictor for immune activation than PD-L1. The gene discussed is HLA-DQB1; the disease is neoplasm.