Correspondingly, in GSEA analyses, the HLA-DQB1high tumours showed enrichment of gene sets related to inflammatory signalling pathways (e.g. IL6/JAK/STAT, TNFα/NFκβ and KRAS) and active immune response (e.g. immune response, T cell activation, granulocytes, complement system, cytokine signalling, leucocyte activation, interferon-γ signalling and inflammatory response) (Supplementary Table 8A, B). This evidence concerns the gene IL6 and neoplasm.