As expected, although HF diet induced a state of metabolic dysfunction, the metabolic alterations promoted by this diet are less intense than the alterations promoted by HFHSu diet: HF diet was incapable of promoting an increase in fasting glycemia, while HFHSu increased significantly glycemia values by 17.3%; HF diet decreased insulin sensitivity by 61.6% and increased glucose intolerance by 20.8% and plasma insulin levels by 67.7% while HFHSu diet exert more pronounced effects on insulin sensitivity, plasma insulin levels and glucose tolerance in comparison with the controls (Table 1). The gene discussed is INS; the disease is hydrops fetalis.