Confirming the inflammatory involvement in endothelial dysfunction, IL-1R and IL-6R expression follow the same pattern of expression than RAGE in both aorta and PA, this being an expected result as it is well described that AGE-RAGE interaction modulates the generation of pro-inflammatory molecules and pathways in endothelial cells in several diseases, including diabetes46,47. Here, IL6R is linked to endothelial dysfunction.